| Expression pattern: |
DN |
| Associated gene: |
MafF |
| Associated microRNA: |
miR-224-5p |
| Biological function: |
inhibits proliferation and promotes apoptosis in HCC cells (tumor-suppressive effect) |
| Molecular mechanism: |
circ-ITCH functions as a miRNA sponge for miR-224-5p, relieving repression of MafF. |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry |
| Clinical significance: |
- |
| Description: |
circ-ITCH is down-regulated in HCC tissues and cell lines. It directly sponges miR-224-5p, thereby increasing MafF expression and contributing to anti-proliferative and pro-apoptotic effects in HCC cells via the circ-ITCH/miR-224-5p/MafF axis. |
| Confidence score: |
0.6996 |