circRNA basic information
circBase ID: hsa_circ_0006732
Name: hsa_circ_ZDHHC20
Synonym: -
Host Gene: ZDHHC20
Genomic location(hg19): chr13:21987790-21999817:-
Genomic location(hg38): chr13:21413651-21425678:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005081
MONDO name: preeclampsia
Disease details: preeclampsia
Disease DO ID:
 10591
Disease MeSH ID:
 D011225
Disease NCIt ID:
 C85021
Disease ICD11 ID:
 229121159
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

placental tissues / PE placenta
Cell lines:

HTR-8/SVneo
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: GRHL2, Argonaute2
Associated microRNA: miR-144
Biological function: represses trophoblast cell proliferation, migration, and invasion
Molecular mechanism: acts as a miR-144 sponge to up-regulate GRHL2
Biological pathway or process:

proliferation (inhibits); migration (inhibits); invasion (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Transfection; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; MTT; Wound Healing Assay; Transwell Assay; Western Blot; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

In preeclampsia placenta, circZDHHC20 is up-regulated and predominantly cytoplasmic. It suppresses trophoblast proliferation, migration, and invasion by sponging miR-144 and thereby relieving miR-144-mediated repression of GRHL2 (circZDHHC20/miR-144/GRHL2 ceRNA axis).
Confidence score:

0.7785
Other information
Title:

CircZDHHC20 represses the proliferation, migration and invasion in trophoblast cells by miR-144/GRHL2 axis.

Journal: Cancer cell international
Published: 2020
PubMed ID: 31956297
Study type:

combined biological and clinical study
Data availability: All data generated or analyzed during this study are included in this published article.
Code availability: -