circRNA basic information
circBase ID: hsa_circ_0023303
Name: hsa_circ_CCND1
Synonym: circ‐CCND1
Host Gene: CCND1
Genomic location(hg19): chr11:69455872-69458759:+
Genomic location(hg38): chr11:69641104-69643991:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005595
MONDO name: laryngeal squamous cell carcinoma
Disease details: laryngeal squamous cell carcinoma
Disease DO ID:
 2876
Disease MeSH ID:
 -
Disease NCIt ID:
 C4044
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

carcinoma tissues; noncancerous tissues; LSCC tissues; adjacent normal tissues
Cell lines:

AMC‐HN‐8; Hep‐2; LSC‐1; TU212; TU177; TU686; SCC10A; NP‐69; 293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: HuR, CCND1
Associated microRNA: miR‐646
Biological function: promotes LSCC cell proliferation and tumor growth
Molecular mechanism: circ-CCND1 binds HuR to enhance CCND1 mRNA stability and sponges miR-646 to relieve repression on CCND1 3′-UTR, coordinately elevating CCND1 expression post-transcriptionally
Biological pathway or process:

proliferation (promotes); cell cycle (promotes); ceRNA regulation (promotes); mRNA stability (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Survival Analysis; Cohort Study; Transfection; Colony Formation Assay; Cell Cycle Assay; In Vivo Animal Model; Western Blot; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Actinomycin D / DRB Stability Assay
Clinical significance:

High circ-CCND1 is associated with aggressive clinical features and shorter overall survival in LSCC
Description:

circ-CCND1 is up-regulated in LSCC and promotes proliferation and xenograft tumor growth. It elevates CCND1 expression post-transcriptionally by binding HuR to enhance CCND1 mRNA stability and by sponging miR-646 to relieve repression on CCND1 3′-UTR; high circ-CCND1 correlates with aggressive features and poorer overall survival.
Confidence score:

0.8215
Other information
Title:

circRNA circ-CCND1 promotes the proliferation of laryngeal squamous cell carcinoma through elevating CCND1 expression via interacting with HuR and miR-646.

Journal: Journal of cellular and molecular medicine
Published: 2020
PubMed ID: 31951319
Study type:

combined biological and clinical study
Data availability: The data sets and supporting materials generated and/or analysed during the current study are available from the corresponding author on reasonable request.
Code availability: -