circRNA basic information
circBase ID: hsa_circ_0088214
Name: hsa_circ_PAPPA
Synonym: -
Host Gene: PAPPA
Genomic location(hg19): chr9:118969734-118989831:+
Genomic location(hg38): chr9:116207455-116227552:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: osteosarcoma
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

hFOB1.19; U2OS; MTX300; HOS; MG63; 143B; ZOS; ZOSM
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: ARID5B, ELL2, PHC2, STAT4
Associated microRNA: miR-33a-3p, miR-205-3141, miR-576-3p
Biological function: unknown
Molecular mechanism: Predicted ceRNA interactions with miRNAs in a circRNA-miRNA-mRNA network; included in a prognosis-related subnetwork built from ARID5B/ELL2/PHC2/STAT4
Biological pathway or process:

ceRNA regulation (other); PI3K/AKT (other); cell cycle (other); other pathway/process (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis; Survival Analysis
Clinical significance:

Included among 8 circRNAs in a circRNA-miRNA-mRNA subnetwork constructed based on four survival-associated mRNAs (ARID5B, ELL2, PHC2, STAT4).
Description:

hsa_circ_0088214 is down-regulated in osteosarcoma (microarray) and is included in the study’s predicted ceRNA network and in the prognosis-related subnetwork linked to four survival-associated mRNAs.
Confidence score:

0.348
Other information
Title:

Construction of a circRNA-miRNA-mRNA network based on competitive endogenous RNA reveals the function of circRNAs in osteosarcoma.

Journal: Cancer cell international
Published: 2020
PubMed ID: 32063749
Study type:

bioinformatics study
Data availability: GSE96964; GSE65071; GSE33382; TARGET
Code availability: -