circRNA basic information
circBase ID: hsa_circ_0006896
Name: hsa_circ_VIRMA
Synonym: circVIRMA(3-4) / circKIAA1429
Host Gene: VIRMA
Genomic location(hg19): chr8:95549330-95550574:-
Genomic location(hg38): chr8:94537102-94538346:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 1060134
MONDO name: atherosclerotic cardiovascular disease
Disease details: carotid atherosclerotic plaque
Disease DO ID:
 -
Disease MeSH ID:
 -
Disease NCIt ID:
 C35771
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood mononuclear cells (PBMCs)
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Potential circulating biomarker to discriminate vulnerable from stable carotid plaques.
Molecular mechanism: Not experimentally validated; included in predicted circRNA-miRNA-mRNA (ceRNA) network analysis.
Biological pathway or process:

ceRNA regulation (other); other pathway/process (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Moderate discriminatory power (ROC) for vulnerable vs stable plaque patients.
Description:

circVIRMA(3-4) is up-regulated in PBMCs from patients with vulnerable carotid plaques and shows moderate ROC-based discrimination versus stable plaques. It was included in an in silico ceRNA network/pathway enrichment analysis, but no direct mechanistic validation was performed.
Confidence score:

0.459
Other information
Title:

Diagnostic potential of circular RNAs in carotid atherosclerotic plaque vulnerability.

Journal: Non-coding RNA research
Published: 2026
PubMed ID: 41809636
Study type:

combined biological and clinical study
Data availability: The raw data supporting the findings of this study are available from the corresponding author upon reasonable request.
Code availability: -