| Expression pattern: |
UP |
| Associated gene: |
SOX4 |
| Associated microRNA: |
miR-590-3p |
| Biological function: |
promotes hypoxia-induced cardiomyocytes injury (reduces viability, induces cell cycle arrest, promotes apoptosis and oxidative stress) |
| Molecular mechanism: |
ceRNA mechanism: circ_0124644 sponges miR-590-3p to regulate SOX4 |
| Biological pathway or process: |
apoptosis (promotes); oxidative stress (promotes); cell cycle (inhibits); proliferation (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Bioinformatics Analysis |
| Clinical significance: |
Circ_0124644 was upregulated in AMI patient serum (potential target for alleviating AMI). |
| Description: |
circ_0124644 is upregulated in AMI patient serum and in hypoxia-treated AC16 cardiomyocytes, where it promotes hypoxia-induced injury. Mechanistically, it acts as a ceRNA that sponges miR-590-3p, thereby increasing SOX4 and aggravating apoptosis/oxidative stress and cell-cycle impairment; circ_0124644 knockdown is protective. |
| Confidence score: |
0.8267 |