circRNA basic information
circBase ID: hsa_circ_0084043
Name: hsa_circ_ADAM9
Synonym: circADAM9
Host Gene: ADAM9
Genomic location(hg19): chr8:38883321-38959449:+
Genomic location(hg38): chr8:39025802-39101930:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005016
MONDO name: diabetic kidney disease
Disease details: diabetic nephropathy / DN
Disease DO ID:
 -
Disease MeSH ID:
 D003928
Disease NCIt ID:
 C84417
Disease ICD11 ID:
 615062102
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum samples
Cell lines:

HMCs
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: USP15, Keap1, Nrf2
Associated microRNA: miR-545-3p
Biological function: Promotes HG-induced human mesangial cell proliferation, migration, inflammation, fibrosis, and oxidative stress; circADAM9 knockdown protects HMCs against HG-induced cell injury.
Molecular mechanism: circADAM9 acts as a miR-545-3p sponge to upregulate USP15 and regulate the Keap1/Nrf2 pathway.
Biological pathway or process:

proliferation (promotes); migration (promotes); inflammation (promotes); fibrosis (promotes); ceRNA regulation (promotes); other pathway/process (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Wound Healing Assay; ELISA; Western Blot
Clinical significance:

May represent a novel therapeutic target for DN treatment.
Description:

circADAM9 is upregulated in serum samples from diabetic nephropathy patients and in high glucose-treated human mesangial cells. It promotes mesangial cell injury, including proliferation, migration, inflammation, fibrosis, and oxidative stress, by sponging miR-545-3p to activate USP15 and inhibit the Keap1/Nrf2 pathway. The study suggests circADAM9 may be a potential therapeutic target for diabetic nephropathy.
Confidence score:

0.7032
Other information
Title:

Circular RNA circADAM9 Promotes Inflammation, Oxidative Stress, and Fibrosis of Human Mesangial Cells via the Keap1-Nrf2 Pathway in Diabetic Nephropathy.

Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
Published: 2023
PubMed ID: 37463596
Study type:

combined biological and clinical study
Data availability: Supplementary Table 1; Supplementary table 2
Code availability: -