| Expression pattern: |
UP |
| Associated gene: |
metastatic tumour antigen 1, hTERT |
| Associated microRNA: |
hsa-miR-490-5p, hsa-miR-224, hsa-miR-1228, hsa-miR-576-5p, hsa-miR-611 |
| Biological function: |
Associated with BRAFV600E mutation in PTC; potential biomarker for diagnosis/progression evaluation. |
| Molecular mechanism: |
Predicted to act as a miRNA sponge (ceRNA-like). |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RNase R Treatment; RT-qPCR; divergent primers PCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Associated with BRAFV600E mutation; AUC for BRAF mutation discrimination reported as 0.7222. |
| Description: |
hsa_circ_0008796 (chr9:22046750-22097364+, host gene CDKN2B-AS1) is up-regulated in PTC and is significantly associated with BRAFV600E mutation. It is predicted to interact with multiple miRNAs, supporting a potential miRNA-sponge role and biomarker utility. |
| Confidence score: |
0.6841 |