| Expression pattern: |
UP |
| Associated gene: |
HAX1 |
| Associated microRNA: |
miR-142-5p |
| Biological function: |
CircGFPT1 promotes ESCC cell growth, proliferation, migration and invasion, inhibits apoptosis, and supports xenograft tumor growth. |
| Molecular mechanism: |
CircGFPT1 functions as a ceRNA by sponging miR-142-5p, thereby up-regulating HAX1 expression to promote ESCC progression and inhibit apoptosis. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; MTT; EdU Staining; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circGFPT1 expression was associated with worse overall survival in ESCC patients and may represent a therapeutic target. |
| Description: |
CircGFPT1 is up-regulated in ESCC tissues and cell lines and high expression is associated with worse overall survival. Functionally, circGFPT1 promotes proliferation, migration, invasion and xenograft tumor growth while suppressing apoptosis. Mechanistically, it acts as a cytoplasmic ceRNA that sponges miR-142-5p to increase HAX1 expression. |
| Confidence score: |
0.8354 |