circRNA basic information
circBase ID: -
Name: -
Synonym: circRNA-14,052 / circRNA-14052
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; adjacent normal tissues
Cell lines:

MCF-7; MDA-MB-231; HEK293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: IKBKB, IL-6, JAK2, STAT3
Associated microRNA: miR-214-3p
Biological function: promotes proliferation, migration and invasion; inhibits apoptosis; promotes xenograft tumor growth
Molecular mechanism: ceRNA mechanism: circRNA-14,052 sponges miR-214-3p to upregulate IKBKB and activate IL-6/JAK2/STAT3 signaling
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); JAK/STAT (promotes); NF-kappaB (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Colony Formation Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; In Vivo Animal Model; H&E Staining; TUNEL; Western Blot; IF (Immunofluorescence); Bioinformatics Analysis
Clinical significance:

-
Description:

circRNA-14,052 is up-regulated in breast cancer tissues and acts as an oncogenic circRNA. It sponges miR-214-3p to de-repress IKBKB, promoting IL-6/JAK2/STAT3 signaling and enhancing malignant phenotypes and xenograft growth.
Confidence score:

0.6545
Other information
Title:

CircRNA-14052 promotes breast cancer progression via miR-214-3p/IKBKB pathway.

Journal: Hereditas
Published: 2025
PubMed ID: 41044672
Study type:

combined biological and clinical study
Data availability: 10.1186/s41065-025-00566-6
Code availability: -