| Expression pattern: |
DN |
| Associated gene: |
SGTB |
| Associated microRNA: |
miR-19a-3p |
| Biological function: |
circ_0001649 inhibits HCC cell proliferation, migration and invasion, promotes apoptosis, and mediates the inhibitory effects of sevoflurane on HCC cell progression. |
| Molecular mechanism: |
circ_0001649 functions through a ceRNA-like mechanism by targeting miR-19a-3p and regulating the downstream target SGTB in sevoflurane-treated HCC cells. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; MTT; EdU Staining; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circ_0001649 is down-regulated in HCC cell lines and is induced by sevoflurane treatment. It suppresses HCC cell proliferation, migration and invasion while promoting apoptosis, and mediates sevoflurane-induced anti-tumor effects through the circ_0001649/miR-19a-3p/SGTB axis. |
| Confidence score: |
0.627 |