| Expression pattern: |
UP |
| Associated gene: |
CLTC, clathrin heavy chain |
| Associated microRNA: |
miR-362-3p |
| Biological function: |
promotes colony formation, proliferation, migration, invasion, metastasis and tumor growth; inhibits apoptosis |
| Molecular mechanism: |
circ_0074027 serves as a sponge of miR-362-3p to upregulate CLTC expression |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
high expression of circ_0074027 was correlated with low differentiation grade and advanced TNM stage; circ_0074027 might be an unfavorable diagnostic and prognostic marker for NSCLC patients |
| Description: |
circ_0074027 is up-regulated in NSCLC tissues and cell lines and is associated with low differentiation grade and advanced TNM stage. It promotes NSCLC cell proliferation, colony formation, migration, invasion and xenograft tumor growth while suppressing apoptosis. Mechanistically, circ_0074027 acts as a miR-362-3p sponge to increase CLTC expression, forming a circ_0074027/miR-362-3p/CLTC regulatory axis. |
| Confidence score: |
0.7416 |