circRNA basic information
circBase ID: hsa_circ_0009061
Name: hsa_circ_KDM1A
Synonym: -
Host Gene: KDM1A
Genomic location(hg19): chr1:23356961-23377013:+
Genomic location(hg38): chr1:23030468-23050520:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008315
MONDO name: prostate cancer
Disease details: prostate cancer / PCa
Disease DO ID:
 10283
Disease MeSH ID:
 D011471
Disease NCIt ID:
 C7378
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PCa tissues; adjacent normal tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Potential diagnostic biomarker for PCa and associated with Gleason score and tumor grade/pathological stage; no direct functional assays were reported for hsa_circ_0009061.
Molecular mechanism: A predicted ceRNA network was constructed for hsa_circ_0009061, but experimentally validated downstream targets were not reported.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

hsa_circ_0009061 had diagnostic value for PCa, with AUC 0.711, and was associated with Gleason score and pathological stage/tumor grade.
Description:

hsa_circ_0009061 is downregulated in PCa tissues and was validated by qRT-PCR in clinical samples. It showed diagnostic biomarker potential and was associated with clinicopathological features including Gleason score and pathological stage/tumor grade, while its mechanism was explored only by predicted ceRNA network analysis.
Confidence score:

0.5047
Other information
Title:

Hsa_Circ_0001206 is downregulated and inhibits cell proliferation, migration and invasion in prostate cancer.

Journal: Artificial cells, nanomedicine, and biotechnology
Published: 2019
PubMed ID: 31198063
Study type:

combined biological and clinical study
Data availability: TCGA
Code availability: -