| Expression pattern: |
DN |
| Associated gene: |
sirt1 |
| Associated microRNA: |
miR-132-3p, miR-212-3p |
| Biological function: |
circ-sirt1 inhibits gastric cancer cell proliferation, migration, invasion, and tumor growth in vivo. |
| Molecular mechanism: |
circ-sirt1 acts as a miRNA sponge for miR-132-3p and miR-212-3p, thereby upregulating sirt1 expression. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (inhibits); migration (inhibits); invasion (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; Colony Formation Assay; Transwell Assay; In Vivo Animal Model; Western Blot |
| Clinical significance: |
These findings may provide a theoretical basis for the classification of GC and a novel therapeutic target for GC patients. |
| Description: |
circ-sirt1 is downregulated in gastric cancer tissues and serum. It functions as a tumor suppressor by inhibiting GC cell proliferation, migration, invasion, and xenograft tumor growth, probably through sponging miR-132-3p/miR-212-3p and upregulating sirt1 expression. |
| Confidence score: |
0.5414 |