| Expression pattern: |
UP |
| Associated gene: |
EPHB4 |
| Associated microRNA: |
- |
| Biological function: |
associated with imatinib resistance, tumor relapse and progression, and metastasis |
| Molecular mechanism: |
not specified |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
H
M
|
| Validation methods: |
Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; ISH (In Situ Hybridization); Clinical Sample Validation; ROC Analysis; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
diagnostic biomarker for distinguishing imatinib-naïve tumors from imatinib-resistant tumor tissues (ROC AUC 0.709); positively correlated with PFS |
| Description: |
circ-EPHB4 (circ_0081518) is upregulated in imatinib-resistant GIST tumor tissues and correlates with imatinib resistance and clinical aggressiveness (relapse/progression/metastasis). It is detectable by ISH with predominant nuclear staining in high-grade malignant tumor cells and shows diagnostic/prognostic relevance in ROC/Kaplan-Meier analyses. |
| Confidence score: |
0.7277 |