| Expression pattern: |
UP |
| Associated gene: |
CDR1 |
| Associated microRNA: |
miR-671-5p, miR-7 |
| Biological function: |
Promotes LUSC migration and metastasis; required for metastatic spread in vivo (axis function). |
| Molecular mechanism: |
miR-671-5p suppresses metastasis by silencing CDR1as and consequently the CDR1as/CDR1 axis (miR-7-independent in this context); CDR1as likely regulates/stabilizes CDR1. |
| Biological pathway or process: |
migration (promotes); metastasis (promotes); EMT (promotes); ceRNA regulation (other) |
| Detected method: |
Q
H
|
| Validation methods: |
RT-qPCR; ISH (In Situ Hybridization); Luciferase Reporter Assay; CLIP; Transfection; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High CDR1as expression was associated with worse survival in non-small cell lung cancer (NSCLC). |
| Description: |
CDR1as is up-regulated in LUSC tumors and is associated with worse patient survival. Functionally, the CDR1as/CDR1 axis promotes LUSC migration and metastasis in vivo, and therapeutic delivery of miR-671-5p inhibits metastasis by silencing CDR1as and CDR1 (largely in a miR-7-independent manner in this context). |
| Confidence score: |
0.6956 |