circRNA basic information
circBase ID: hsa_circ_0003221
Name: hsa_circ_PTK2
Synonym: circPTK2
Host Gene: PTK2
Genomic location(hg19): chr8:141856358-141900868:-
Genomic location(hg38): chr8:140846259-140890769:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004986
MONDO name: urinary bladder carcinoma
Disease details: bladder cancer
Disease DO ID:
 4007
Disease MeSH ID:
 -
Disease NCIt ID:
 C4912
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

SW780; UM-UC-3
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: PTK2, PABPC1, SETDB1
Associated microRNA: mir129-5p
Biological function: promotes proliferation, invasion and cell cycle progression; inhibits apoptosis when upregulated; knockdown inhibits proliferation and invasion and promotes apoptosis
Molecular mechanism: ceRNA mechanism / miRNA sponge for mir129-5p
Biological pathway or process:

proliferation (promotes); invasion (promotes); cell cycle (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; MTT; EdU Staining; Colony Formation Assay; Transwell Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry
Clinical significance:

potential for treatment of bladder cancer and improvement of prognosis
Description:

circPTK2 promotes bladder cancer cell proliferation, invasion, and cell cycle progression, while its knockdown suppresses these malignant phenotypes and promotes apoptosis. The study suggests that circPTK2 acts as a miRNA sponge for mir129-5p, supporting a ceRNA-type regulatory mechanism in bladder cancer.
Confidence score:

0.4236
Other information
Title:

Protein Tyrosine Kinase 2 Circular RNA Promotes Proliferation and Invasion of Bladder Cancer.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Published: 2025
PubMed ID: 40654029
Study type:

biological research
Data availability: -
Code availability: -