| Expression pattern: |
UP |
| Associated gene: |
EIF4G2 / eukaryotic translation initiation factor 4gamma2 |
| Associated microRNA: |
miR-885-5p |
| Biological function: |
Promotes NSCLC cell proliferation, migration, invasion, EMT, metastasis, tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
circ_0102899 acts as a ceRNA by binding miR-885-5p and regulating EIF4G2 to promote malignant behavior and EMT in NSCLC. |
| Biological pathway or process: |
ceRNA regulation (promotes); EMT (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; Survival Analysis |
| Clinical significance: |
High circ_0102899 expression is associated with tumor size, lymph node metastasis, TNM stage, recurrence and metastasis risk, and poor prognosis in NSCLC patients. |
| Description: |
hsa_circ_0102899 is up-regulated in NSCLC tissues and cell lines and is associated with adverse clinicopathological features and poor prognosis. Functionally, it promotes NSCLC malignant progression, including proliferation, migration, invasion, EMT, metastasis, and xenograft tumor growth, partly by acting through the miR-885-5p/EIF4G2 regulatory axis. |
| Confidence score: |
0.8326 |