| Expression pattern: |
UP |
| Associated gene: |
MEF2D, AGO2 |
| Associated microRNA: |
miR-451a |
| Biological function: |
circ_0084615 functions as a miRNA sponge in B[a]P-treated liver cancer cells and contributes to hepatocarcinogenesis through regulation of miR-451a and MEF2D. |
| Molecular mechanism: |
circ_0084615 acts as a miRNA sponge for miR-451a and regulates the downstream target MEF2D in a circRNA-miRNA-mRNA axis. |
| Biological pathway or process: |
ceRNA regulation (promotes); immune regulation (other); other pathway/process (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Microarray; FISH / smFISH; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
The circ_0084615/miR-451a/MEF2D axis may provide insight into B[a]P-induced liver cancer and potential food contaminant-related disease mechanisms, but no direct diagnostic or prognostic clinical association for circ_0084615 expression was reported. |
| Description: |
circ_0084615 is up-regulated in B[a]P-treated liver cancer cells and localizes to the cytoplasm. The study supports a circ_0084615/miR-451a/MEF2D regulatory axis that may contribute to B[a]P-associated hepatocarcinogenesis. |
| Confidence score: |
0.7006 |