circRNA basic information
circBase ID: hsa_circ_0004846
Name: hsa_circ_SAMD4A
Synonym: circ_0004846 / circ_SAMD4A
Host Gene: SAMD4A
Genomic location(hg19): chr14:55168779-55169298:+
Genomic location(hg38): chr14:54702061-54702580:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005075
MONDO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid carcinoma / PTC
Disease DO ID:
 3969
Disease MeSH ID:
 -
Disease NCIt ID:
 C4035
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PTC tissues; paracancerous tissues
Cell lines:

BCPAP; TPC-1; IHH-4; Nthy-ori 3-1; 293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: PELI1
Associated microRNA: miR-142-3p
Biological function: Promotes PTC cell proliferation, migration and invasion; activates PI3K/AKT signaling; increases vimentin expression.
Molecular mechanism: Acts as a ceRNA/miRNA sponge for miR-142-3p to upregulate PELI1, leading to activation of the PI3K/AKT pathway.
Biological pathway or process:

PI3K/AKT (promotes); proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

divergent primers PCR; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; Transduction; CCK8; Colony Formation Assay; EdU Staining; Transwell Assay; Western Blot; IF (Immunofluorescence)
Clinical significance:

-
Description:

hsa_circ_0004846 is upregulated in papillary thyroid carcinoma tissues and cell lines and promotes proliferation, migration, and invasion. It functions as a ceRNA by sponging miR-142-3p to increase PELI1 expression, thereby activating PI3K/AKT signaling.
Confidence score:

0.7183
Other information
Title:

hsa_circ_0004846 enhances the malignant phenotype of papillary thyroid carcinoma cells via the miR‑142‑3p/PELI1 axis.

Journal: Oncology letters
Published: 2025
PubMed ID: 40070794
Study type:

combined biological and clinical study
Data availability: The data generated in the present study may be requested from the corresponding author.
Code availability: -