| Expression pattern: |
UP |
| Associated gene: |
ENO1, GSK3beta |
| Associated microRNA: |
- |
| Biological function: |
Promotes GC cell proliferation and migration; suppresses ferroptosis; activates glycolysis; promotes tumor growth in vivo. |
| Molecular mechanism: |
circTUBGCP3 encodes TUBGCP3-230aa; the peptide binds/stabilizes ENO1 by inhibiting ubiquitination; ENO1/TUBGCP3-230aa recruits GSK3beta to suppress AMPK phosphorylation, enhancing glycolysis and inhibiting ferroptosis via system Xc-/GPX4. |
| Biological pathway or process: |
glycolysis (promotes); ferroptosis (inhibits); proliferation (promotes); migration (promotes); ubiquitination (inhibits); AMPK (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; ROC Analysis; Transfection; EdU Staining; Colony Formation Assay; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; Co-IP; IP (Mass Spectrometry); Western Blot; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
ROC curve analysis suggested circTUBGCP3 expression correlates with lymph node metastasis; circTUBGCP3 may serve as a diagnostic and prognostic biomarker in GC. |
| Description: |
circTUBGCP3 is up-regulated in gastric cancer and promotes proliferation, migration, and xenograft growth. It encodes TUBGCP3-230aa, which stabilizes ENO1 and modulates AMPK/system Xc-/GPX4 signaling to enhance glycolysis and inhibit ferroptosis. |
| Confidence score: |
0.8768 |