circRNA basic information
circBase ID: hsa_circ_0005273
Name: hsa_circ_PTK2
Synonym: hsa_circRNA_104700 / circ-PTK2
Host Gene: PTK2
Genomic location(hg19): chr8:141710989-141716304:-
Genomic location(hg38): chr8:140700890-140706205:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009693
MONDO name: plasma cell myeloma
Disease details: multiple myeloma
Disease DO ID:
 9538
Disease MeSH ID:
 D009101
Disease NCIt ID:
 C3242
Disease ICD11 ID:
 1582389689; 526287100
Disease OMIM ID:
 254500
Species: Human
Species details: Homo sapiens
Tissue specimen:

bone marrow plasma cells
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: PTK2
Associated microRNA: miR-1298-5p
Biological function: promotes neoplastic progression; associated with poor treatment response and survival
Molecular mechanism: may act as a miRNA sponge (ceRNA); may increase expression of its paternal gene PTK2
Biological pathway or process:

ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis; Bioinformatics Analysis
Clinical significance:

correlated with poor treatment response and survival
Description:

circ-PTK2 is up-regulated in multiple myeloma bone marrow plasma cells and has diagnostic value. Higher circ-PTK2 is associated with worse treatment response and poorer survival, and it is proposed to promote MM progression via miRNA sponging and/or enhancing PTK2 expression.
Confidence score:

0.636
Other information
Title:

Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma.

Journal: BMC cancer
Published: 2020
PubMed ID: 31948430
Study type:

combined biological and clinical study
Data availability: available from the corresponding author on reasonable request
Code availability: -