| Expression pattern: |
DN |
| Associated gene: |
SCAI |
| Associated microRNA: |
miR-424-5p |
| Biological function: |
suppresses OSCC cell proliferation, migration, invasion and glycolysis; inhibits tumor growth in vivo |
| Molecular mechanism: |
acts as a molecular sponge of miR-424-5p to regulate SCAI expression |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); glycolysis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Western Blot; Luciferase Reporter Assay; Transfection; MTT; Transwell Assay; In Vivo Animal Model; Clinical Sample Validation |
| Clinical significance: |
circGDI2 as a novel exosome-based cancer biomarker and therapeutic agent for OSCC treatment |
| Description: |
In OSCC, circGDI2 is down-regulated and can be transported via exosomes. Exosomal circGDI2 suppresses malignant behaviors (proliferation, migration, invasion) and glycolysis by sponging miR-424-5p, thereby increasing SCAI expression, and it inhibits tumor growth in vivo. |
| Confidence score: |
0.721 |