| Expression pattern: |
UP |
| Associated gene: |
MMP2, Ago2 |
| Associated microRNA: |
miR-136-5p, miR-874-3p, miR-299-3p |
| Biological function: |
promotes metastasis, migration, invasion and EMT; accelerates tumor growth |
| Molecular mechanism: |
Exosome-delivered circ_MMP2 functions as a ceRNA to sponge miR-136-5p, thereby upregulating its host gene MMP2 and promoting metastatic phenotypes. |
| Biological pathway or process: |
metastasis (promotes); migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); H&E Staining; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circ_MMP2 level is associated with metastatic HCC tissues and lower overall survival of HCC patients. |
| Description: |
In hepatocellular carcinoma, exosome-transmitted circ_MMP2 is upregulated in metastatic tissues and promotes migration/invasion, EMT and metastasis. Mechanistically it acts as a ceRNA that sponges miR-136-5p to upregulate MMP2, and high circ_MMP2 is associated with worse overall survival. |
| Confidence score: |
0.8931 |