| Expression pattern: |
DS |
| Associated gene: |
197 target genes |
| Associated microRNA: |
hsa-miR-497-5p, hsa-miR-195-5p, hsa-miR-4661-5p, hsa-miR-450b-5p, hsa-miR-1269a, hsa-miR-338-3p, hsa-miR-424-5p |
| Biological function: |
May act as a ceRNA in an ESCC circRNA-miRNA-mRNA coexpression network; it was positioned at the centre of a prognostic-related hub gene subnetwork. |
| Molecular mechanism: |
Predicted ceRNA mechanism within a circRNA-miRNA-mRNA network. |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
hsa_circ_0081168 was identified as one of five dysregulated circRNAs in an ESCC ceRNA network and was described as being central in a subnetwork involving prognostic-related hub genes. The study did not further experimentally characterize its individual mechanism beyond sequencing, qRT-PCR-supported selection and bioinformatic network analysis. |
| Confidence score: |
0.4685 |