| Expression pattern: |
UP |
| Associated gene: |
MYO6 |
| Associated microRNA: |
miR-455-3p |
| Biological function: |
promotes CRC cell proliferation, migration and invasion; inhibits apoptosis; promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA (miRNA sponge) mechanism: circCSNK1G1 sponges miR-455-3p to increase MYO6 expression |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); cell cycle (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Western Blot; In Vivo Animal Model; Clinical Sample Validation |
| Clinical significance: |
circCSNK1G1 might be a useful biomarker for CRC treatment |
| Description: |
circCSNK1G1 is up-regulated in colorectal cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes malignant phenotypes and xenograft tumor growth by sponging miR-455-3p, thereby increasing MYO6 expression (circCSNK1G1/miR-455-3p/MYO6 axis). |
| Confidence score: |
0.8207 |