circRNA basic information
circBase ID: hsa_circ_0001400
Name: hsa_circ_RELL1
Synonym: -
Host Gene: RELL1
Genomic location(hg19): chr4:37633006-37640126:-
Genomic location(hg38): chr4:37631384-37638504:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005150
MONDO name: age-related macular degeneration
Disease details: age-related macular degeneration / AMD
Disease DO ID:
 10871
Disease MeSH ID:
 -
Disease NCIt ID:
 C84391
Disease ICD11 ID:
 1514301548
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

macular AMD RPE/choroid samples
Cell lines:

ARPE-19
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: associated with pathological AMD events in oxidative stress and inflammation RPE cell models (role predicted via ceRNA network)
Molecular mechanism: competitive endogenous RNA network (circRNA-miRNA-mRNA)
Biological pathway or process:

ceRNA regulation (other); HIF-1 signaling (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0001400 is up-regulated in both oxidative stress and inflammatory ARPE-19 AMD models and is part of the predicted circRNA-miRNA-mRNA ceRNA network constructed in this study, whose downstream enrichment highlights HIF-1 signaling as a common event.
Confidence score:

0.2465
Other information
Title:

Circular RNA expression and the competitive endogenous RNA network in pathological, age-related macular degeneration events: A cross-platform normalization study.

Journal: Journal of biomedical research
Published: 2023
PubMed ID: 37366063
Study type:

combined biological and clinical study
Data availability: GSE29801; GSE50195; GSE135092
Code availability: -