| Expression pattern: |
UP |
| Associated gene: |
SNRPA, NOTCH1, NICD1, Snail, E-cadherin, Vimentin |
| Associated microRNA: |
miR-625-5p |
| Biological function: |
Promotes migration, invasion, EMT-like process, and metastasis of HCC cells. |
| Molecular mechanism: |
circSEC62 functions as a miR-625-5p sponge to upregulate SNRPA expression and activate the NOTCH1/Snail pathway. |
| Biological pathway or process: |
ceRNA regulation (promotes); Notch (promotes); EMT (promotes); migration (promotes); invasion (promotes); metastasis (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Microarray; Bioinformatics Analysis; RNA Pull-Down; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Clinical Sample Validation; Survival Analysis; Transfection; Transwell Assay; IF (Immunofluorescence); Western Blot; In Vivo Animal Model; H&E Staining |
| Clinical significance: |
circSEC62 was overexpressed in HCC and higher expression was associated with poorer OS and RFS, suggesting unfavorable survival and potential therapeutic relevance in metastatic HCC. |
| Description: |
circSEC62 is up-regulated in HCC, especially MVI-HCC, and its high expression is associated with poorer OS and RFS. It promotes HCC cell migration, invasion, EMT-like changes, and lung metastasis by sponging miR-625-5p, thereby increasing SNRPA expression and activating the NOTCH1/Snail pathway. |
| Confidence score: |
0.8658 |