| Expression pattern: |
UP |
| Associated gene: |
PRMT5 |
| Associated microRNA: |
miR-204-5p |
| Biological function: |
promotes proliferation, migration, invasion, and epithelial-mesenchymal transition; inhibits apoptosis; promotes tumor growth |
| Molecular mechanism: |
ceRNA mechanism: circRHOT1 sponges miR-204-5p to increase PRMT5 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; IHC (Immunohistochemistry); ROC Analysis; In Vivo Animal Model |
| Clinical significance: |
Exosomal circRHOT1 showed diagnostic value for distinguishing breast cancer patients from healthy controls (AUC = 0.8300). |
| Description: |
Exosomal circRHOT1 is up-regulated in breast cancer patient serum exosomes, tumor tissues, and breast cancer cells. It promotes breast cancer proliferation, migration/invasion and EMT while inhibiting apoptosis by sponging miR-204-5p, thereby increasing PRMT5 expression; circRHOT1 knockdown in exosomes suppresses tumor growth in nude mice. |
| Confidence score: |
0.7892 |