circRNA basic information
circBase ID: hsa_circ_0072088
Name: hsa_circ_ZFR
Synonym: circ_0072088
Host Gene: ZFR
Genomic location(hg19): chr5:32379220-32388780:-
Genomic location(hg38): chr5:32379114-32388674:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; matched adjacent normal tissues
Cell lines:

16 HBE; H1299; A549
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: WT1
Associated microRNA: miR-1225-5p
Biological function: promotes NSCLC cell malignant behavior (migration, invasion, glycolysis) and inhibits apoptosis; promotes tumor growth in vivo
Molecular mechanism: ceRNA mechanism: circ_0072088 sponges miR-1225-5p to regulate WT1 expression
Biological pathway or process:

migration (promotes); invasion (promotes); glycolysis (promotes); apoptosis (inhibits); proliferation (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; Transwell Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; Bioinformatics Analysis
Clinical significance:

-
Description:

circ_0072088 is up-regulated in NSCLC tissues and cell lines and mainly localizes to the cytoplasm. It promotes malignant phenotypes (migration, invasion, glycolysis, and tumor growth) by acting as a ceRNA that sponges miR-1225-5p and upregulates WT1.
Confidence score:

0.6815
Other information
Title:

Circular non-coding RNA circ_0072088 serves as a ceRNA, targeting the miR-1225-5p/WT1 axis to regulate non-small cell lung cancer cell malignant behavior.

Journal: Thoracic cancer
Published: 2023
PubMed ID: 37220935
Study type:

combined biological and clinical study
Data availability: The data sets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -