| Expression pattern: |
UP |
| Associated gene: |
CCNA2 |
| Associated microRNA: |
miR-188-3p |
| Biological function: |
Circ_0104206 promotes CC cell proliferation, colony formation, migration, and in vivo tumor development. |
| Molecular mechanism: |
Circ_0104206 functions as an oncogenic circRNA by targeting miR-188-3p and governing the downstream CCNA2 network. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
Circ_0104206 may be a potential marker for CC, but its clinical implications need further evidence. |
| Description: |
Circ_0104206 is up-regulated in colon cancer tissues and cell lines. It acts as an oncogenic circRNA that promotes CC cell proliferation, colony formation, migration, and xenograft tumor growth, at least partly through the miR-188-3p/CCNA2 regulatory axis. |
| Confidence score: |
0.7795 |