| Expression pattern: |
UP |
| Associated gene: |
zeb1 |
| Associated microRNA: |
miR-130a-5p |
| Biological function: |
Facilitates colorectal cancer cell proliferation and promotes migration and invasion; circWHSC1 knockdown promotes apoptosis and causes G0/G1 arrest; enhances tumor growth in nude mice. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-130a-5p to promote zeb1 expression, supporting a ceRNA mechanism; phenotypes rescued by miR-130a-5p inhibition or zeb1 overexpression. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); EMT (promotes); cell cycle (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; FISH / smFISH; Transfection; CCK8; Colony Formation Assay; EdU Staining; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Wound Healing Assay; Western Blot; Luciferase Reporter Assay; RNA Pull-Down; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circWHSC1 is up-regulated in colorectal cancer cell lines and predominantly localizes to the cytoplasm. It promotes CRC cell proliferation, migration/invasion and tumor growth by sponging miR-130a-5p and thereby increasing zeb1 expression; miR-130a-5p inhibition or zeb1 overexpression rescues circWHSC1-knockdown phenotypes. |
| Confidence score: |
0.7801 |