| Expression pattern: |
UP |
| Associated gene: |
KLF12, Ago2 |
| Associated microRNA: |
miR-654-3p |
| Biological function: |
Promotes CRC cell proliferation, migration, invasion, stemness and tumor growth; inhibits apoptosis. |
| Molecular mechanism: |
Acts as a ceRNA by sponging miR-654-3p to upregulate KLF12. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); stemness (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Sanger Sequencing; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
High expression of circ_0084188 was associated with an advanced clinical stage in CRC patients. |
| Description: |
circ_0084188 is up-regulated in colorectal cancer tissues/cells and mainly localizes to the cytoplasm. It promotes CRC proliferation, migration, invasion, stemness and tumor growth while inhibiting apoptosis by sponging miR-654-3p to upregulate KLF12 (circ_0084188/miR-654-3p/KLF12 ceRNA axis). High circ_0084188 expression is associated with advanced clinical stage. |
| Confidence score: |
0.8465 |