| Expression pattern: |
UP |
| Associated gene: |
PGK1, Ago2 |
| Associated microRNA: |
miR-556-5p |
| Biological function: |
promotes proliferation, glycolysis and enzalutamide resistance in prostate cancer cells |
| Molecular mechanism: |
circROBO1 acts as a ceRNA by sponging miR-556-5p to relieve repression of PGK1, thereby accelerating glycolysis and promoting enzalutamide resistance |
| Biological pathway or process: |
glycolysis (promotes); proliferation (promotes); drug resistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circROBO1 (hsa_circ_0124696) is up-regulated in prostate cancer tissues and cell lines and mainly localized in the cytoplasm. It promotes proliferation, enhances glycolysis, and increases enzalutamide resistance by sponging miR-556-5p to upregulate the glycolytic enzyme PGK1. |
| Confidence score: |
0.8246 |