| Expression pattern: |
UP |
| Associated gene: |
SGK1 |
| Associated microRNA: |
miR-455-5p |
| Biological function: |
circ_0007142 facilitates CRC progression by promoting cell proliferation, migration and invasion, inhibiting apoptosis, and supporting xenograft tumor growth; circ_0007142 knockdown suppresses these malignant phenotypes. |
| Molecular mechanism: |
circ_0007142 functions as a miR-455-5p sponge to regulate SGK1 expression through a ceRNA mechanism. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; MTT; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
circ_0007142 may provide a new therapeutic target for CRC. |
| Description: |
circ_0007142 is up-regulated in CRC tissues and cell lines. It promotes CRC cell proliferation, migration, invasion and xenograft tumor growth while inhibiting apoptosis, at least partly by sponging miR-455-5p and thereby regulating SGK1. The study suggests the circ_0007142/miR-455-5p/SGK1 axis as a potential therapeutic target for CRC. |
| Confidence score: |
0.7591 |