| Expression pattern: |
UP |
| Associated gene: |
E2F3, Ago2 |
| Associated microRNA: |
hsa‐miR‐665 |
| Biological function: |
promotes proliferation, migration, invasion, angiogenesis, tumorigenesis and lung metastasis of colorectal cancer cells |
| Molecular mechanism: |
ceRNA mechanism: hsa_circ_0081069 sponges miR-665 to relieve repression of E2F3 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); angiogenesis (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; Tube Formation Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); H&E Staining; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High hsa_circ_0081069 expression is associated with advanced tumor stage and poor prognosis in CRC patients; suggested as a prognostic marker. |
| Description: |
hsa_circ_0081069 (derived from COL1A2) is upregulated in colorectal cancer and mainly localized in the cytoplasm. It promotes malignant phenotypes (proliferation, migration/invasion, angiogenesis, tumor growth and metastasis) by sponging miR-665 and thereby increasing E2F3 expression, and high expression is associated with poor patient prognosis. |
| Confidence score: |
0.8712 |