| Expression pattern: |
DN |
| Associated gene: |
SMAD7 |
| Associated microRNA: |
- |
| Biological function: |
Circ LARP4 suppresses NSCLC metastasis and inhibits NSCLC cell migration and invasion; its low expression is associated with poor disease-free survival. |
| Molecular mechanism: |
Circ LARP4 inhibits NSCLC cell migration and invasion by up-regulating SMAD7 expression. |
| Biological pathway or process: |
migration (inhibits); invasion (inhibits); metastasis (inhibits); proliferation (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; Wound Healing Assay; Transwell Assay; Western Blot; Survival Analysis |
| Clinical significance: |
Low circ LARP4 expression is associated with poor disease-free survival and poor prognosis in NSCLC patients, suggesting potential prognostic value. |
| Description: |
Circ LARP4 is down-regulated in NSCLC tissues and cell lines. Higher circ LARP4 expression is associated with better disease-free survival, and overexpression suppresses NSCLC cell migration, invasion, and metastasis-associated behavior by up-regulating SMAD7 expression. |
| Confidence score: |
0.6148 |