| Expression pattern: |
UP |
| Associated gene: |
FOXK1 |
| Associated microRNA: |
miR-485-5p |
| Biological function: |
circAPLP2 promotes CRC cell proliferation, migration, invasion, metastasis, EMT, aerobic glycolysis and tumor growth, and inhibits apoptosis; circAPLP2 knockdown suppresses these malignant phenotypes and facilitates apoptosis. |
| Molecular mechanism: |
circAPLP2 functions as a ceRNA/miRNA sponge for miR-485-5p to positively regulate FOXK1 expression, thereby promoting CRC progression and aerobic glycolysis. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); glycolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
circAPLP2 expression was higher in advanced pathological stages and may be a possible prognostic biomarker and promising target for CRC treatment. |
| Description: |
circAPLP2 is up-regulated in colorectal cancer tissues and cell lines and is associated with more advanced pathological stage. Functionally, circAPLP2 promotes CRC proliferation, migration, invasion, EMT, glycolysis and xenograft tumor growth while suppressing apoptosis. Mechanistically, circAPLP2 acts as a ceRNA for miR-485-5p to increase FOXK1 expression, forming the circAPLP2/miR-485-5p/FOXK1 axis. |
| Confidence score: |
0.7591 |