| Expression pattern: |
UP |
| Associated gene: |
FBLN2 |
| Associated microRNA: |
miR-1292-5p |
| Biological function: |
promotes sorafenib resistance and suppresses ferroptosis in HCC cells |
| Molecular mechanism: |
circ_0001944 sponges/targets miR-1292-5p, relieving repression of FBLN2 and thereby rearranging iron homeostasis and lipid peroxidation to inhibit ferroptosis, leading to sorafenib resistance |
| Biological pathway or process: |
ferroptosis (inhibits); drug resistance (promotes); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; RT-qPCR; Bioinformatics Analysis; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Western Blot; In Vivo Animal Model |
| Clinical significance: |
Circ_0001944 is a putative target for reversing sorafenib resistance in HCC. |
| Description: |
In sorafenib-resistant HCC cells, circ_0001944 is up-regulated and promotes sorafenib resistance. It directly targets miR-1292-5p to regulate the miR-1292-5p/FBLN2 axis, leading to suppression of ferroptosis (reduced iron overload/ROS/lipid peroxidation). |
| Confidence score: |
0.7164 |