| Expression pattern: |
UP |
| Associated gene: |
CBX4, wnt4, beta-catenin |
| Associated microRNA: |
miR-21-5p |
| Biological function: |
Promotes LC progression by enhancing proliferation, migration, invasion and suppressing apoptosis; promotes tumor growth in vivo. |
| Molecular mechanism: |
Acts as a ceRNA by sponging miR-21-5p to relieve repression of CBX4, and activates Wnt4/beta-catenin signaling (inhibition of circ_PVT1 inactivates this pathway). |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); cell cycle (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; FISH / smFISH; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; TUNEL; ELISA; Western Blot; IF (Immunofluorescence); In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Clinical Sample Validation |
| Clinical significance: |
- |
| Description: |
circ_PVT1 is up-regulated in laryngeal cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes LC cell proliferation, cell-cycle progression, migration and invasion while inhibiting apoptosis, at least partly by sponging miR-21-5p to regulate CBX4 and activate Wnt4/beta-catenin signaling; its knockdown suppresses xenograft tumor growth. |
| Confidence score: |
0.7492 |