| Expression pattern: |
UP |
| Associated gene: |
ZBTB48, MKRN3, IGF2BP3, HSPB1 |
| Associated microRNA: |
- |
| Biological function: |
Promotes glioblastoma progression by enhancing GSC proliferation and stemness and enabling ferroptosis evasion (ferroptosis resistance), including lowering Fe2+ accumulation. |
| Molecular mechanism: |
circRNF10 binds ZBTB48 and increases its protein stability by reducing MKRN3-mediated K48-linked ubiquitination; ZBTB48 transcriptionally upregulates HSPB1 and IGF2BP3; IGF2BP3 binds circRNF10 to enhance its RNA stability, forming a circRNF10/ZBTB48/IGF2BP3 positive feedback loop that remodels iron metabolism and suppresses ferroptosis. |
| Biological pathway or process: |
proliferation (promotes); stemness (promotes); ferroptosis (inhibits); mitochondrial function (other); iron metabolism (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RNA Pull-Down; RIP (RNA Immunoprecipitation); Co-IP; ChIP / ChIP-seq; Luciferase Reporter Assay; Actinomycin D / DRB Stability Assay; Transfection; MTT; EdU Staining; Cell Cycle Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Survival Analysis; Bioinformatics Analysis; ubiquitination; RNA-seq |
| Clinical significance: |
circRNF10 is positively correlated with glioma grade and high circRNF10 expression is associated with poor prognosis. |
| Description: |
circRNF10 (hsa_circ_0028912) is up-regulated in glioblastoma/glioma and high expression associates with poor prognosis. It promotes GSC proliferation and stemness by inhibiting ferroptosis and remodeling iron metabolism, via binding/stabilizing ZBTB48 (through blocking MKRN3-mediated ubiquitination) and forming a positive feedback loop with ZBTB48-driven IGF2BP3 and IGF2BP3-mediated circRNF10 stabilization, with downstream HSPB1 upregulation. |
| Confidence score: |
0.8991 |