circRNA basic information
circBase ID: hsa_circ_0035445
Name: hsa_circ_ALDH1A2
Synonym: -
Host Gene: ALDH1A2
Genomic location(hg19): chr15:58302846-58306479:-
Genomic location(hg38): chr15:58010648-58014281:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma
Cell lines:

HCT116; SW480; SW620; NCM460
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Meaningfully associated with CRC cell proliferation and metastasis (inferred from enrichment/association statements).
Molecular mechanism: Predicted ceRNA (circRNA-miRNA-mRNA) network via bioinformatics.
Biological pathway or process:

proliferation (other); metastasis (other); ceRNA regulation (other); MAPK (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

ROC analysis suggests diagnostic value in CRC plasma; included in combined 3-circRNA diagnostic panel with higher AUC.
Description:

hsa_circ_0035445 is down-regulated in CRC patient plasma (and shows the same trend in CRC cell lines) and has potential diagnostic value by ROC analysis, including as part of a 3-circRNA diagnostic panel. Its downstream mechanism was explored via predicted circRNA-miRNA-mRNA (ceRNA) network and enrichment analysis (including MAPK signaling pathway in predictions).
Confidence score:

0.5047
Other information
Title:

A 3-circular RNA signature as a noninvasive biomarker for diagnosis of colorectal cancer.

Journal: Cancer cell international
Published: 2019
PubMed ID: 31700498
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -