| Expression pattern: |
UP |
| Associated gene: |
CUL4B, Ago2 |
| Associated microRNA: |
miR-198 |
| Biological function: |
circMFN2 promotes OC cell proliferation, migration, invasion, glycolysis, and tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
circMFN2 acts as a ceRNA by sponging miR-198 to upregulate CUL4B expression, thereby promoting OC progression and glycolysis. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); glycolysis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; Colony Formation Assay; EdU Staining; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Survival Analysis; Cohort Study |
| Clinical significance: |
circMFN2 was upregulated in OC tissues; low circMFN2 expression was associated with a higher 5-year survival rate, indicating that high circMFN2 expression predicts poor prognosis. |
| Description: |
circMFN2 is upregulated in ovarian cancer tissues and cells and is associated with poorer survival. Functionally, circMFN2 promotes OC cell proliferation, migration, invasion, glycolysis, and in vivo tumor growth while inhibiting apoptosis. Mechanistically, circMFN2 acts through the miR-198/CUL4B axis. |
| Confidence score: |
0.8427 |