| Expression pattern: |
UP |
| Associated gene: |
MMP7, COL1A1 |
| Associated microRNA: |
hsa-miR-144-3p, hsa-miR-577 |
| Biological function: |
Promotes PDAC cell migration and elevates MMP7 and COL1A1 expression. |
| Molecular mechanism: |
Functions as a competing endogenous RNA (ceRNA) miRNA sponge for hsa-miR-144-3p and hsa-miR-577, thereby enhancing MMP7 and COL1A1 expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); migration (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RNase R Treatment; RT-qPCR; Bioinformatics Analysis; Transfection; Wound Healing Assay; Western Blot; Luciferase Reporter Assay; Clinical Sample Validation |
| Clinical significance: |
Potential biomarker in PDAC diagnosis and therapy. |
| Description: |
hsa_circRNA_0007334 is up-regulated in PDAC tissues and promotes malignant behavior (migration) in PANC-1 cells. It acts as a ceRNA by sponging hsa-miR-144-3p and hsa-miR-577 to increase MMP7 and COL1A1 expression, and is proposed as a potential PDAC diagnostic/therapeutic biomarker. |
| Confidence score: |
0.7291 |