| Expression pattern: |
UP |
| Associated gene: |
TRAF6 |
| Associated microRNA: |
miR-543 |
| Biological function: |
circRASA2 accelerated the pathological process of periodontitis in vitro; knockdown of circRASA2 promoted proliferation, migration and osteogenic differentiation of LPS-treated PDLCs. |
| Molecular mechanism: |
circRASA2 acts as a sponge for miR-543 to up-regulate TRAF6 expression, thereby promoting periodontitis progression in vitro. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (inhibits); migration (inhibits); other pathway/process (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Western Blot |
| Clinical significance: |
- |
| Description: |
In an LPS-induced human PDLC periodontitis model, circRASA2 was up-regulated and promoted pathological injury. Silencing circRASA2 increased PDLC proliferation, migration and osteogenic differentiation, apparently by releasing miR-543 and reducing TRAF6 expression. The study suggests circRASA2 as a potential therapeutic target for periodontitis. |
| Confidence score: |
0.5554 |