| Expression pattern: |
UP |
| Associated gene: |
AGO2 |
| Associated microRNA: |
miR-451a, miR-148a-3p, miR-122-5p |
| Biological function: |
circ_0075320 is up-regulated in B[a]P-treated liver cancer cells and acts as a potential miRNA sponge associated with B[a]P-induced hepatocarcinogenesis and liver cancer metastasis. |
| Molecular mechanism: |
circ_0075320 functions as a potential cytoplasmic miRNA sponge and is enriched with AGO2, supporting involvement in a circRNA-miRNA regulatory mechanism. |
| Biological pathway or process: |
ceRNA regulation (other); migration (other); metastasis (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Microarray; FISH / smFISH; RIP (RNA Immunoprecipitation); Bioinformatics Analysis |
| Clinical significance: |
circ_0075320 was identified as a B[a]P-upregulated circRNA and potential key RNA in liver cancer metastasis, but no direct diagnostic or prognostic clinical association for circ_0075320 expression was reported. |
| Description: |
circ_0075320 is up-regulated in B[a]P-treated liver cancer cells and was validated as a circular, cytoplasmic RNA with AGO2 enrichment. The study proposes that circ_0075320 may act as a miRNA sponge and a key RNA associated with liver cancer metastasis, although a complete downstream mRNA axis was not experimentally established for this circRNA. |
| Confidence score: |
0.5215 |