| Expression pattern: |
UP |
| Associated gene: |
AK4, Ago2 |
| Associated microRNA: |
miR-556-3p |
| Biological function: |
promotes lung cancer progression and cisplatin resistance; knockdown inhibits proliferation and migration and promotes apoptosis and cisplatin sensitivity |
| Molecular mechanism: |
circ-ABCB10 acts as a miRNA sponge for miR-556-3p to upregulate AK4 (ceRNA mechanism), thereby reducing cisplatin sensitivity |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); ceRNA regulation (promotes); drug resistance (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; TUNEL; Transwell Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circ-ABCB10 is upregulated in NSCLC cell lines and mainly localizes to the cytoplasm. It sponges miR-556-3p to relieve repression of AK4, thereby promoting malignant phenotypes and reducing cisplatin sensitivity; circ-ABCB10 knockdown enhances cisplatin response in vitro. |
| Confidence score: |
0.7918 |