circRNA basic information
circBase ID: hsa_circ_0003427
Name: hsa_circ_ABCC1
Synonym: circ-ABCC1
Host Gene: ABCC1
Genomic location(hg19): chr16:14989970-16387509:+
Genomic location(hg38): chr16:14896113-16293652:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

MCF7; MDA-MB-231; MCF7-R; MDA-MB-231-R; HEK293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: ABCC1, AGO2
Associated microRNA: miR-627-5p
Biological function: Circ-ABCC1 enhances radioresistance of breast cancer cells; circ-ABCC1 knockdown suppresses viability and proliferation and facilitates apoptosis of radio-resistant BC cells.
Molecular mechanism: ceRNA mechanism: circ-ABCC1 acts as a miR-627-5p sponge/decoy to up-regulate ABCC1 expression at the post-transcriptional level.
Biological pathway or process:

radioresistance (promotes); proliferation (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Transfection; CCK8; Colony Formation Assay; Luciferase Reporter Assay; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0003427, termed circ-ABCC1, is up-regulated in radio-resistant breast cancer cells. It promotes breast cancer cell radioresistance by sponging miR-627-5p and thereby increasing ABCC1 expression; circ-ABCC1 knockdown suppresses viability and proliferation and promotes apoptosis in radio-resistant BC cells.
Confidence score:

0.6716
Other information
Title:

Circ-ABCC1 enhances radioresistance of breast cancer cells via miR-627-5p/ABCC1 axis.

Journal: Cellular and molecular biology (Noisy-le-Grand, France)
Published: 2022
PubMed ID: 37114252
Study type:

biological research
Data availability: starBase website (https://starbase.sysu.edu.cn/)
Code availability: -