| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-203 |
| Biological function: |
Promotes migratory ability and malignant progression of esophageal cancer; high circ-PRMT5 level is positively correlated with lymphatic metastasis and distant metastasis. |
| Molecular mechanism: |
circ-PRMT5 promotes esophageal cancer cell migration by binding and targeting miR-203, with a negative correlation between circ-PRMT5 and miR-203 levels. |
| Biological pathway or process: |
migration (promotes); metastasis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; Transwell Assay; Wound Healing Assay; Luciferase Reporter Assay |
| Clinical significance: |
circ-PRMT5 level was positively correlated to the rates of lymphatic metastasis and distant metastasis of esophageal cancer patients, suggesting it may be a biomarker for predicting malignant progression. |
| Description: |
circ-PRMT5 is up-regulated in esophageal cancer tissues and cell lines. It promotes migratory ability and malignant progression of esophageal cancer cells by targeting/binding miR-203, and its high expression is associated with lymphatic and distant metastasis. |
| Confidence score: |
0.6369 |