| Expression pattern: |
UP |
| Associated gene: |
GLUD1, Ago2 |
| Associated microRNA: |
miR-497-5p |
| Biological function: |
CircDPP4 promotes PCa cell growth, proliferation, colony formation, motility, invasion and tumorigenicity, and inhibits apoptosis. |
| Molecular mechanism: |
CircDPP4 acts as a miR-497-5p sponge to relieve miR-497-5p-mediated suppression of GLUD1, thereby increasing GLUD1 expression and promoting malignant phenotypes of PCa cells. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
CircDPP4 provides a possible therapy target for PCa. |
| Description: |
CircDPP4 is up-regulated in prostate cancer tissues and cell lines. It promotes PCa cell proliferation, growth, motility, invasion and xenograft tumorigenicity while suppressing apoptosis. Mechanistically, circDPP4 sponges miR-497-5p to increase GLUD1 expression, forming a circDPP4/miR-497-5p/GLUD1 regulatory axis and suggesting circDPP4 as a potential therapeutic target. |
| Confidence score: |
0.8299 |