| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Acts as a biomarker for cervical cancer occurrence; associated with lymph node metastasis and FIGO stage. |
| Molecular mechanism: |
Not specified for exosomal circSLC26A4 in this study. |
| Biological pathway or process: |
metastasis (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis |
| Clinical significance: |
Plasma exosomal circSLC26A4 can be used as a diagnostic marker for CC; ROC AUC=1.000 for differentiating CC patients from normal controls. |
| Description: |
This study shows that exosomal circSLC26A4 is up-regulated in cervical cancer cell line-derived exosomes and in plasma exosomes from CC patients. Plasma exosomal circSLC26A4 demonstrates strong diagnostic potential (ROC analysis) and its higher levels are associated with lymph node metastasis and higher FIGO stage. |
| Confidence score: |
0.4187 |