| Expression pattern: |
UP |
| Associated gene: |
CCND2, Ago2 |
| Associated microRNA: |
miR-149 |
| Biological function: |
Promotes HCC cell proliferation, migration, and invasion; facilitates cell cycle progression; inhibits apoptosis; promotes tumor growth in vivo. |
| Molecular mechanism: |
circMMP9 acts as a miRNA sponge for miR-149 to enhance CCND2 expression (ceRNA mechanism). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); cell cycle (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Survival Analysis; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); Transfection; CCK8; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
High circMMP9 expression correlates with poor prognosis in HCC patients; associated with tumor differentiation and TNM stage. |
| Description: |
circMMP9 is up-regulated in HCC tissues and cell lines and its high expression is associated with poorer overall survival. Functionally, circMMP9 promotes proliferation, migration, invasion, cell-cycle progression and tumor growth, partly by sponging miR-149 to increase CCND2 expression (circMMP9/miR-149/CCND2 ceRNA axis). |
| Confidence score: |
0.8201 |