| Expression pattern: |
UP |
| Associated gene: |
HDAC4, ABCC1 |
| Associated microRNA: |
miR-591 |
| Biological function: |
Promotes osteosarcoma cell viability, proliferation, migration, invasion and tumor growth; inhibits apoptosis and autophagy. |
| Molecular mechanism: |
circABCC1 acts as a ceRNA by sponging miR-591 to upregulate HDAC4 expression, thereby regulating osteosarcoma progression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); autophagy (inhibits); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
circABCC1 is up-regulated in osteosarcoma tissues and cell lines and functions as a pro-oncogenic circRNA. Its knockdown suppresses osteosarcoma cell proliferation, migration, invasion and xenograft tumor growth while promoting apoptosis and autophagy, mainly through the circABCC1/miR-591/HDAC4 regulatory axis. |
| Confidence score: |
0.6835 |