circRNA basic information
circBase ID: hsa_circ_0058148
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr2:216283964-216288249:-
Genomic location(hg38): chr2:215419241-215423526:-
Subcellular localization: nucleus
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

breast cancer tissues; paired-paracancerous tissues
Cell lines:

BT-474; BT-549; MCF-7; MDA-MB-231; MDA-MB-453; T47D; MCF-10A
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: unknown
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; divergent primers PCR; Sanger Sequencing; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation
Clinical significance:

-
Description:

hsa_circ_0058148 was identified as up-regulated in breast cancer tissues and cell lines and validated as a circular RNA, predominantly localized in the nucleus. Its knockdown did not affect breast cancer cell migration in this study, and no specific mechanism was established.
Confidence score:

0.5739
Other information
Title:

A novel feedback regulated loop of circRRM2-IGF2BP1-MYC promotes breast cancer metastasis.

Journal: Cancer cell international
Published: 2023
PubMed ID: 36966311
Study type:

combined biological and clinical study
Data availability: GSE111504
Code availability: -