| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-1238 |
| Biological function: |
Circ_0000502 promotes OS cell proliferation, migration, invasion, metastatic properties, and tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
Circ_0000502 functions as a miRNA sponge for miR-1238, and its oncogenic properties are partially dependent on suppression of miR-1238. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Luciferase Reporter Assay; Survival Analysis; Cohort Study; Bioinformatics Analysis |
| Clinical significance: |
High circ_0000502 expression is associated with larger tumor size, advanced WHO grade, worse 5-year overall survival, and an independent prognostic role in OS patients. |
| Description: |
Circ_0000502 is up-regulated in osteosarcoma tissues and cell lines and is associated with more severe clinicopathological features and poor overall survival. Functionally, it promotes OS cell proliferation, migration, invasion, and xenograft tumor growth while suppressing apoptosis. Mechanistically, circ_0000502 acts at least partly by sponging miR-1238. |
| Confidence score: |
0.7524 |